Partial oral vs. I.V. antibiotic treatment of endocarditis

A Danish noninferiority trial investigated the effect of switching from standard I.V. antibiotic treatment to an oral regimen after stabilizing patients with infective endocarditis on the left side of the heart. All 400 participants received at least 10 days of I.V.

A Danish noninferiority trial investigated the effect of switching from standard I.V. antibiotic treatment to an oral regimen after stabilizing patients with infective endocarditis on the left side of the heart. All 400 participants received at least 10 days of I.V. antibiotics and were in stable condition when they were randomized to either continue that treatment or to begin oral antibiotics instead. The primary endpoint—a composite of all-cause mortality, unplanned cardiac surgery, embolic events, and relapse of bacteremia with the primary pathogen—affected about 12% of patients in the I.V. group. The incidence rate was 9% among those treated with oral antibiotics, thereby demonstrating this delivery route as noninferior to I.V. administration.