Clinical implications of revised pooled cohort equations for estimating atherosclerotic CVD risk

Collaborators from several universities worked together to modernize the 2013 pooled cohort equations (PCEs) that help inform prevention guidelines for cardiovascular disease (CVD).

Collaborators from several universities worked together to modernize the 2013 pooled cohort equations (PCEs) that help inform prevention guidelines for cardiovascular disease (CVD). The existing PCEs overstated risk of stroke, nonfatal myocardial infarction, or death from coronary heart disease by about 20%, with African Americans especially affected. To improve the clinical accuracy of these risk projections, the investigators coupled more recent data—from six cohorts including an aggregate 26,700 adults with no history of CVD—with newer statistical approaches. Under the revised PCEs, they report, the population of people previously categorized as high risk would be cut by roughly 11.8 million. The research, funded by the National Institutes of Health, also suggests that risk equations will become outdated over time and will need to be updated on a regular basis.